• br Methods br Results Our study

  2020-12-08

  

  Methods Results Our study focused on consecutive postural adjustments (CPAs) between IS and BS (the shaded areas on Fig. 2); that is to say, the Rx kinetics that occur after the end of an upper limb movement. It was dedicated to examining the main features of CPAs and the influence of movement

• The enzyme cyclooxygenase COX or prostaglandin endoperoxide

  2020-12-08

  

  The enzyme cyclooxygenase (COX) or prostaglandin endoperoxide H synthase (PGHS) is the key enzyme in the conversion of arachidonic THZ531 (AA) into prostaglandins (PGs) [1]. In 1991, researchers found that there were two isoforms of this enzyme called COX-1 and COX-2 with independent genes and diff

• Introduction Safety critical systems are defined as those sy

  2020-12-08

  

  Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated within

• The serotonin transporter gene encodes an integral membrane

  2020-12-08

  

  The serotonin transporter gene () encodes an integral membrane protein that transports serotonin from the synaptic spaces into the presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent way. This protein is a target of psychomotor stimulants

• The BDNF Val Met polymorphism is also associated with decrea

  2020-12-08

  

  The BDNF Val66Met polymorphism is also associated with decreased dendritic arborization and impaired long-term potentiation [25]. This is particularly important for the hippocampus, and healthy individuals with a BDNF Val66Met allele have decreased hippocampal volumes [30]. Hippocampal atrophy is co

• Introduction Angiotensin II Ang II and Endothelin

  2020-12-07

  

  Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1]. Cardiac hypertrophy, ischemic arrhythmia, and stroke have been associated to an overstimulation of the angiotensin II type 1 (AT1) recepto

• In the present study promoting bile acid synthesis by

  2020-12-07

  

  In the present study, promoting bile ras gtpase synthesis by activating EP4 receptors was shown to exert protection against hepatic steatosis. This finding may be relevant for treatment of non-alcoholic fatty liver disease, a major cause of liver disease and prominent indication for liver transplan

• br Materials and methods br Results We examined the effects

  2020-12-07

  

  Materials and methods Results We examined the effects of curcumin in Fluo-4 loaded SH-EP1 Quercetin dihydrate stably transfected with human α7-nACh receptor. Application of curcumin alone in the concentrations up to 100 μM for 30 sec. did not induce any detectable change in intracellular Ca2+

• In conclusion our study has demonstrated that

  2020-12-07

  

  In conclusion, our study has demonstrated that PGE2 stimulates expression of survivin in hepatocellular carcinoma cells. Although there are 4 subtypes of EP receptors, the EP1 receptor appears to be the predominant receptor that regulates PGE2-induced expression of survivin, mainly through trans-act

• The GH family includes also xylanases which are not

  2020-12-07

  

  The GH30 family includes also xylanases which are not MeGlcA-dependent. Most of them are grouped to GH30_7 subfamily that includes XynIV from Trichoderma reesei showing exo- and endo-xylanase activity [11] and XYLD from Bispora sp. MEY-1 [12] having activity towards glucuronoxylan and arabinoxylan,

• br No Evidence for Further ET

  2020-12-07

  

  No Evidence for Further ET-Receptor Subtypes Further receptor subclassifications have been proposed including suggestions that ETB could be subdivided into ETB1, present on endothelial cells, and ETB2 on smooth muscle cells, but there currently is no evidence that the receptors expressed by these

• Introduction Pain is frequently the first clinical symptom

  2020-12-07

  

  Introduction Pain is frequently the first clinical symptom of head and neck carcinoma. Indeed, pain is the initial reason leading ∼70% of cancer patients to seek professional assistance (Lam & Schmidt, 2011; Rettig & D’Souza, 2015; Schmidt, 2014). Clinically, cancer-induced facial pain can be evoke

• streptozotocin A decrease in heme levels enables

  2020-12-07

  

  A decrease in heme levels enables the phosphorylation of eIF2α by HRI and thereby inhibition of eIF2α activity. Indeed, the relatively small change in cytosolic heme levels in SZ streptozotocin showed downstream functional consequences manifested by almost 50% elevation in the phosphorylation of eI

• 4-P-PDOT Here we report that ILC s sensed oxysterols through

  2020-12-07

  

  Here, we report that ILC3s sensed oxysterols through GPR183, which was highly expressed by LTi-like ILC3s. 7α,25-OHC-synthesizing enzymes were produced by fibroblastic stromal 4-P-PDOT found in intestinal lymphoid structures, and the GPR183 ligand 7α,25-OHC acted as a chemoattractant for ILC3s. GPR

• Several studies have indicated that ICT induces activation o

  2020-12-07

  

  Several studies have indicated that ICT induces activation of ERK and p38 kinase in a variety of cells. The ERK pathway was involved in and partly contributed to the neuroprotective effects in rat neuronal HOSu [14] and anticancer effects in several cancer cells [5], [7], [8]. ICT could also simulta

16387 records 782/1093 page Previous Next First page 上5页 781782783784785 下5页 Last page