• Although encoded by a single gene GR displays considerable

  2021-11-25

  

  Although encoded by a single gene, GR displays considerable heterogeneity through the combined effects of alternative mRNA splicing, alternative translation initiation, and complex post-translational modification. Differential expression of the various GR isoforms may contribute to tissue-specific f

• br Introduction G protein coupled

  2021-11-25

  

  Introduction G-protein coupled receptors (GPCRs) represent one of the largest family of receptors involved in cell membrane signal transduction and have become one of the leading therapeutic targets worldwide (Chakraborty and Chattopadhyay, 2015; Bouvier, 2001; Sriram and Insel, 2018). GPCRs sign

• br Acknowledgments We apologize to the researchers who were

  2021-11-25

  

  Acknowledgments We apologize to the researchers who were not referenced due to space limitations. We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. This work was supported by grants from the US National Institu

• Septic shock a condition where

  2021-11-25

  

  Septic shock, a condition where endothelium-derived substances most likely play an important role, is often accompanied by cardiac dysfunction, pulmonary hypertension, systemic hypotension and impaired oxygen utilisation with systemic acidosis (Vincent, 1998). Experimental endotoxaemia shows a simil

• In addition JMJ proteins respond to biotic stress

  2021-11-25

  

  In addition, JMJ proteins respond to biotic stress and abiotic stress in plants. Rice genes OsJMJ704 and OsJMJ705, which have demethylase activities of H3K27me2/3 and H3K4me2/3, respectively, regulate defense-related genes and affect the defense ability of rice against bacterial pathogen Xoo (Li et

• We observed that the Toc

  2021-11-25

  

  We observed that the Toc159G domain recognizes the N-terminal portion of the transit peptide of pSSU with a dissociation constant of 70 μM (Fig. 2; Table 1), while a tenfold higher KD was obtained for the phosphorylated C-terminal region. In turn, the homodimer of Toc34G recognizes the phosphorylate

• In order to investigate whether this off target activity was

  2021-11-24

  

  In order to investigate whether this off-target activity was related to a particular structural feature of this Adenine HCl australia or was characteristic of the series, compounds , and were selected as being matched pairs with compound but with structural variation in terms of the R, R and R group

• Morin is a flavonoid that has shown

  2021-11-24

  

  Morin is a flavonoid that has shown to have effective anti-inflammatory and anti-tumor function [118]. Morin was able to block the activation of NF-κB pathway by ROS and inflammatory cytokines, preventing a signaling cascade resulting in cell death [121]. Morin exerted its control over the signaling

• One may carefully evaluate the concept pancreas derived

  2021-11-24

  

  One may carefully evaluate the concept ‘pancreas derived GLP-1′ as this may dependent on the specificity of the a good chance used in immunohistochemistry or radiommunoassays. If either a side-viewing antibody or a C-terminal wrapping antibody raised against GLP-1 is applied one may also identify N-

• For many plasma membrane receptors

  2021-11-24

  

  For many plasma membrane receptors including GPCRs, their density on the cell-surface is finely controlled by various transcriptional, post-transcriptional and post-translational mechanisms, and is often a determinant of overall receptor function in a cell. To date, the transcriptional regulation an

• We have previously designed an azobenzene based

  2021-11-24

  

  We have previously designed an azobenzene-based molecule, Razo, which could switch the conformations of G-quadruplex structures by photoregulation. 12, 13, 14, 15 However, it lacks selectivity to different G-quadruplexes. Therefore, we want to find a way to modify this molecule so that it could be u

• br The Farnesoid X receptor FXR identification and ligands

  2021-11-24

  

  The Farnesoid X receptor (FXR): identification and ligands The Farnesoid X receptor (FXR) belongs to a family of proteins called Nuclear Receptors (NRs). NRs are a class of ligand-activated transcription factors, which transactivate networks of target genes, thereby mediating a wide range of phys

• ikk pathway A species specific diverse number of

  2021-11-24

  

  A species-specific diverse number of FPPS genes are present in insect genomes (Zhang and Li, 2008, Cusson et al., 2006). The genome of the yellow fever mosquito Aedes aegypti contains a single FPPS gene (AaFPPS) that is highly expressed in the CA (Nouzova et al., 2011). FPPS catalytic activity in th

• Data of initial analogs have

  2021-11-24

  

  Data of initial analogs (±)-– have been shown in wherein SAR was observed for the intended change of the right-hand side pyridin-3-yl ring of to various other -containing heteroaryl ring (Ar) disposing the ring- at different directions. Based on consistent human and rat FAAH potency as well as int

• In addition the interplay of membrane curvature induced tens

  2021-11-24

  

  In addition the interplay of membrane curvature induced tension at the fusion pore and ret pathway induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity warrant further re

16450 records 570/1097 page Previous Next First page 上5页 566567568569570 下5页 Last page