• In this work we constructed a

  2021-12-13

  

  In this work, we constructed a versatile platform based on MoS2-loaded molecular beacon(MB) and HCR for miRNA detection with high sensitivity and low-background. In this method, the G-quadruplex/Thioflavin T (THT) as fluorescent signal output, which possesses a variety of advantages, such as label-f

• Recently we indicated that cell motility was regulated

  2021-12-13

  

  Recently, we indicated that cell motility was regulated by the different induction of GPR120 and GPR40 in liver epithelial WB-F344 glucocorticoid receptors treated with chemical agents. The cell motility of WB-F344 cells was stimulated by phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) whi

• In the FARM motifs of GGPPSs hydrophobic amino acids

  2021-12-13

  

  In the FARM motifs of GGPPSs, hydrophobic b-AP15 are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP synthase (GGPPS) ac

• br FAAH regulation of ECB signaling

  2021-12-13

  

  FAAH regulation of ECB signaling ECBs are fatty Cy5 NHS ester (non-sulfonated) mg amides and monoacylglyerols functioning as neuromodulator lipids that exhibit rapid (within seconds) on-demand biosynthesis in response to neuronal activation, and are subsequently degraded by specialized catabolic

• A new series of pyrimidones with C

  2021-12-13

  

  A new series of pyrimidones (14) with C-7 and C-9 modifications were furnished consisting of a hydroxypyridinone and a thiazole ring and checked against raltegravir resistant HIV mutant strains to determine their in vitro anti-HIV IN potency. Compounds 14a–14a, 14b–14b and 14c–14c appeared with 6.4 

• br Results and Discussion The Set sequence is homologous

  2021-12-13

  

  Results and Discussion The Set7 sequence is homologous to the other identified histone methyltransferases in S. pombe (Figure S1) and also shares similarity with human HMTases, H3K9 GLP/Ga9, and H4K20 SUV420H1 (Figure S1). Set7 fused with the GFP (Set7-GFP) localized in the nucleus and cytoplasm

• Pharmacological G a inhibition resulted in significant reduc

  2021-12-13

  

  Pharmacological G9a inhibition resulted in significant reduction of viable BTC cells in a concentration- and cell line–dependent manner. Interestingly, we found a significant correlation between BIX01294-IC50 and UNC0642-IC50 values in our BTC cell model—both inhibitors competitively inhibit H3K9 su

• The following are the supplementary data related

  2021-12-10

  

  The following are the supplementary data related to this article. Transparency document Introduction Hypoxia is a pathological process that causes abnormal changes in metabolism, function and morphological structure of tissue because of insufficient oxygen supply. It's reported that hypoxia w

• Our investigation also showed NAC increased

  2021-12-10

  

  Our investigation also showed NAC increased the level of DAF and might protect HUVECs from complement activation. NAC, an antioxidant/mucous modifier, has displayed benefits in chronic obstructive pulmonary disease. Martinez de Lizarrondo et al [38] provided evidence that the molecular target underl

• Interestingly myorelaxation and the stimulation of cGMP

  2021-12-10

  

  Interestingly, myorelaxation and the stimulation of cGMP production are properties also reported for sGC stimulators, such as YC-1 and BAY 41–2272 (i.e., indazole compounds that were discovered in the 1990s) [35]. They relax aortic ring contractions induced by phenylephrine, and their effects are si

• It was reported that GPR

  2021-12-10

  

  It was reported that GPR120 is expressed on macrophages in adipose tissue (Oh et al., 2010). Whether GPR120-positive SB 747651A dihydrochloride in human and rat pancreas belongs to macrophages was studied. CD68 is a transmembrane glycoprotein that is highly expressed by human monocytes and tissue m

• Transporters are important ta http

  2021-12-10

  

  Transporters are important targets for devising new therapies, optimizing existing therapies, and helping understand the toxicities of certain drugs. Given the well-documented role of transporters in restricting the distribution of drugs, modulating the relevant transporters could enhance the permea

• Based on the collective experience to

  2021-12-10

  

  Based on the collective experience to date, it is likely that a much more comprehensive assessment of GSI selectivity for inhibition of multiple substrates, as well as biomarkers to track inhibition of non-APP substrates in vivo will be needed to support future efforts to develop substrate selective

• br Memories can last a lifetime long after

  2021-12-10

  

  Memories can last a lifetime, long after the transient events have passed. The fact that information stored in the dna methyltransferase can outlast the environmental trigger implies that enduring cellular changes in the central nervous system underlie memory. Epigenetic modifications of DNA and

• The finding of histamine action on

  2021-12-10

  

  The finding of histamine action on ASICs also raises the question about possible action of other histamine receptor ligands. In the present work we selected several compounds and performed electrophysiological testing of their action on recombinant homomeric ASIC1a and ASIC2a. Nα-methylhistamine is

16400 records 557/1094 page Previous Next First page 上5页 556557558559560 下5页 Last page