• Toxoplasma gondii is an exceptionally tractable apicomplexan

  2022-08-17

  

  Toxoplasma gondii is an exceptionally tractable apicomplexan parasite that expresses a limited yet representative subset of apicomplexan cyclase orthologs, making it an ideal model for investigating cyclic nucleotide signaling in Apicomplexa. Of the five putative nucleotide cyclases, only TgACα1 and

• In summary we have successfully identified a

  2022-08-17

  

  In summary, we have successfully identified a series of potent and selective GSNOR inhibitors having imidazole and tetrazole functional groups in both end of the core structure and many compounds have been identified with IC: Introduction Peppers (Capsicum annuum L.), tomatoes and potatoes, belon

• Introduction Multiple sclerosis MS a

  2022-08-17

  

  Introduction Multiple sclerosis (MS), a neurological autoimmune disease, is driven by CD4+ pkm2 of the T helper (TH) cells [1]. There is no curative treatment for MS and the present treatments typically focus on immunomodulation for slowing the progression of the disease. These includes interferon

• This study does have important limitations to consider The u

  2022-08-17

  

  This study does have important limitations to consider. The utilization of a recombinant gp120 monomer (at a single concentration of 100 ng/ml) instead of live virus particles may limit the validity of our results. Moreover, extrapolation of an in vitro cell culture model to animals or humans cannot

• br Acknowledgments br Introduction Manipulating target prote

  2022-08-17

  

  Acknowledgments Introduction Manipulating target protein expression via either induction or suppression of gene expression is a powerful technology that has been widely used in the recent past in the field of neurobiology, both to study the pathophysiological significance of a target gene and

• br Methods GLUT DS was diagnosed

  2022-08-17

  

  Methods GLUT1DS was diagnosed either when analysis of the SLC2A1 gene showed a pathogenic mutation and/or when cerebrospinal fluid (CSF) analysis met the criteria for GLUT1DS: a CSF VSV-G Peptide below the 10th percentile, a cerebrospinal fluid (CSF) to blood ratio below the 25th percentile and

• Since the isoflavone emerged as privileged scaffold in Hh in

  2022-08-17

  

  Since the isoflavone emerged as privileged scaffold in Hh inhibition, based on molecular modeling predictions and prior studies [17,22], here we designed a number of isoflavones able to interact preferentially with the Smo receptor or the Gli protein. Molecules were synthesized by means of a novel s

• The usefulness of GIP R antagonism for the

  2022-08-17

  

  The usefulness of GIP-R antagonism for the treatment of obesity-diabetes has been revealed in numerous studies employing knockout or chemical blockade of GIP-R signalling.*88, 89, *90, 91, 92, 93, 94, 95, 96, *97 For example, sub-chronic daily administration of (Pro3)GIP to ob/ob mice results in sig

• br Methods br Results br Discussion The measurement

  2022-08-17

  

  Methods Results Discussion The measurement of intraocular pressure was made with a commercially available rebound tonometer, the Tonovet®. In our studies, Tonovet® underestimated the intraocular pressure in both animal models, being this effect more pronounced in the rat. To study the effe

• We reviewed the results of comprehensive genomic

  2022-08-16

  

  We reviewed the results of comprehensive genomic profiling (CGP) in 26,054 cases of NSCLC and examined the frequency and clinical characteristics of patients whose tumors harbor FGFR fusions. To our knowledge, this is the most in-depth evaluation of FGFR fusions exclusively in NSCLC. Here we will de

• It has been reported that aberrant GPR expressions were dete

  2022-08-16

  

  It has been reported that aberrant GPR120 expressions were detected in colorectal carcinomas, compared with normal tissues. In addition, GPR120 stimulated cell motile activity and angiogenic property in colon cancer cells [10]. Recently, we indicated that GPR40 suppressed cell motile and invasive ac

• Liposomes that are less than nm in

  2022-08-16

  

  Liposomes that are less than 200nm in diameter are necessary to optimize uptake of liposomes by Roxithromycin (Oesterling et al., 2014). The liposomes constructed in these experiments were found to be sufficiently small in diameter for use in in vivo and in vitro experiments. Even smaller diameters

• br Materials and methods br

  2022-08-16

  

  Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either Ion Channel Compound Library H1 or H2 receptors, 2) histamine H1 and H2 receptor inverse agonists crossdesensitize

• p neurotrophin receptor p NTR or CD

  2022-08-16

  

  p75 neurotrophin receptor (p75NTR or CD271), a member of the tumor necrosis factor receptor superfamily, has been implicated in several steps of glioma tumorgenesis [5]. p75NTR mediates glioma invasion and progression through γ-secretase-dependent and -independent mechanisms [6], [7], and its expres

• clofibrate br Financial support This study was supported by

  2022-08-16

  

  Financial support This study was supported by Grant PH-102-PP-11, PH-103-PP-11 from the National Health Research Institutes, Taiwan. Conflict of interest Please refer to the accompanying ICMJE disclosure forms for further details. Authors’ contributions Acknowledgements Introduction

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