• However T DM and associated hyperglycemia can adversely affe

  2022-09-15

  

  However, T1DM and associated hyperglycemia can adversely affect the structure and function of the heart in several mechanisms including inhibiting the anabolic effect of insulin due to its deficiency, generation of higher levels of ROS and induction of lipid peroxidation, and subsequent activation o

• Introduction Histone is the core component of chromatin

  2022-09-15

  

  Introduction Histone is the core component of chromatin and histone modification is one of the key mechanisms of epigenetic regulation (Bannister and Kouzarides, 2011). Amino Talabostat mesylate residues on histone tails can be modified under different mechanisms including acetylation, methylation

• Treatment with histamine had no effect

  2022-09-15

  

  Treatment with histamine had no effect on histamine H1 receptor expression in HepG2 Chrysin (Fig. 1), while knockdown of histamine H1 receptor expression prevented histamine from repressing apo A-I gene expression (Fig. 2). Overexpression of the histamine H1 receptor regulated apo A-I promoter acti

• This study was supported by the Finance Department Foundatio

  2022-09-15

  

  This study was supported by the Finance Department Foundation of Jilin Province (3D5178963428). Introduction Breast cancer is one of the leading cause of death in women worldwide [1,2]. Due to recent advances of combined therapies, survival rate of breast has improved significantly. However, bre

• Several studies have found that GPR possesses a distinct pha

  2022-09-09

  

  Several studies have found that GPR55 possesses a distinct pharmacology from that of CB1 and CB2, and that only certain cannabinoids act at this receptor. In transfected Ciclopirox ethanolamine expressing hGPR55, out of more than 20 synthetic and endogenous cannabinoids evaluated, only 2 compounds,

• Molecular mechanisms of decidualization have been studied fo

  2022-09-09

  

  Molecular mechanisms of decidualization have been studied for years, revealing numerous signaling pathways and transcriptional factors participated in the regulation [37,38]. As a central controller of deicdualization, FOXO1 regulates the transcription of a large number of target genes, which are in

• A subsequent modeling study by a different group

  2022-09-09

  

  A subsequent modeling study by a different group was based on the bovine rhodopsin homology model using the 1L9H construct [38]. However, the site-directed mutagenesis data and docking suggested that the niacin-binding pocket is different to that described in the aforementioned report, but similar t

• br Materials and methods br Results br Discussion Until very

  2022-09-09

  

  Materials and methods Results Discussion Until very recently, the anti-atherogenic activity of niacin was attributed almost exclusively to its impact on HDL and other plasma lipids, perhaps mediated via its action on GPR109A expressed in adipose or other tissues. However, recent clinical st

• GSK1210151A br Materials and methods br Results br Discussio

  2022-09-09

  

  Materials and methods Results Discussion The GO system is an important mechanism for maintaining the integrity of genetic material in many eukaryotic organisms. This is demonstrated by the high conservation, across different evolutionary lineages, of the sequences of the proteins that compo

• To verify the feasibility of the proposed

  2022-09-09

  

  To verify the feasibility of the proposed method, EIS is firstly adopted to study the modification processes of the electrode. As shown in Fig. 1A, the nyquist plot of bare gold electrode exhibits a straight line, which indicates a fast charge transfer process (curve a). After modified with probe a,

• br Materials and methods br

  2022-09-09

  

  Materials and methods Results Discussion l-glutamate is the major excitatory neurotransmitter in the brain, and is functionally involved in many processes of the nervous system which have been connected with several neurological diseases [4]. These conditions are characterized by the time-d

• br Methods br Results br

  2022-09-09

  

  Methods Results Discussion Significant alterations in the expression of genes related to the glutamatergic system have been shown in several experimental models of epilepsy; however, in most studies focused on acute changes or modifications in expression, these were investigated during the

• br Introduction Maintaining blood glucose within an

  2022-09-09

  

  Introduction Maintaining blood glucose within an appropriate range is crucial for survival. In diabetes, those who suffer episodes of severe hypoglycemia have an increased risk of death [1], [2]. The BINA is especially dependent on an adequate, continuous supply of circulating glucose to fuel met

• The main aim of our study

  2022-09-09

  

  The main aim of our study was to identify whether glucokinase and Irs2 were required for beta cell replication induced by short-term HF diet feeding. Glucokinase plays a critical role in regulating blood glucose levels by catalysing the rate-limiting biochemical reaction of glycolysis [26,27]. In pa

• br Results br Discussion ER and GR

  2022-09-09

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

16403 records 405/1094 page Previous Next First page 上5页 401402403404405 下5页 Last page