• br Acknowledgments R Dalmann has obtained a bourse Cifre

  2022-09-07

  

  Acknowledgments R. Dalmann has obtained a “bourse Cifre” (grant 304/2011) from the ‘Association Nationale de la Recherche Technique’ and Bristol-Myers-Squibb. Introduction Endocannabinoids, their molecular targets (receptors), their synthetic and degrading enzymes and proteins that transport

• Following the discovery of diketo compounds S

  2022-09-07

  

  Following the discovery of β-diketo compounds S-1360 [31] and L-731988 [32] as anti-HIV integrase inhibitors, a group of researchers discovered a potent fty720 based derivative (1) as the inhibitor of HIV integrase functioning at the 3′-processing and strand transfer steps of HIV integrase. Bioassa

• Allergic rhinitis characterized by inflammation of the nasal

  2022-09-07

  

  Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to CU CPT 4a receptor in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggering alle

• Histamine functions as a key neurotransmitter

  2022-09-07

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, histamine is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway

• br Conclusion The addition of cellulose to natural substrate

  2022-09-06

  

  Conclusion The addition of URMC-099 to natural substrate increases the number of H-bonds which indicates an increase in the stability of the docking systems. The investigated compounds are more stable than natural substrate in docking systems, where the natural substrate has two H-bonds while th

• While the specific set of challenges

  2022-09-06

  

  While the specific set of challenges associated with deorphanization and transforming each poorly characterized GPCR into a useful drug target will be unique, much can be learned by considering how these issues have been addressed for other receptors. One group of poorly characterized GPCRs that hav

• br Endogenous and synthetic ligands of GPR There are current

  2022-09-06

  

  Endogenous and synthetic ligands of GPR55 There are currently limited commercially available synthetic agonists and antagonists that are specific for GPR55. A large number of studies have investigated the pharmacology of GPR55 4, 23, 25, 30, 31, 32, 33, 34, 35, with contradictory findings reporte

• DPQ Selection of the month br Fibrosis br Liver protection

  2022-09-06

  

  Selection of the month Fibrosis Liver protection device Non-alcoholic steatohepatitis Genetic metabolic liver disease Hepatitis C virus (HCV) infection Hepatitis B virus (HBV) infection Cirrhosis Regeneration Introduction Upon catalysis by hepatic and bacterial enzymes, c

• br Xenobiotics and the Glucocorticoid Receptor br Conclusion

  2022-09-03

  

  Xenobiotics and the Glucocorticoid Receptor Conclusion Transparency document Acknowledgements The author wishes to thank Professor Wilhelm Engström from the Swedish University of Agricultural Sciences (Department of Biomedical Sciences and Veterinary Public Health) for his proof reading

• br Acknowledgements br Introduction Glucagon a amino acid

  2022-09-03

  

  Acknowledgements Introduction Glucagon, a 29-amino CBL0137 hydrochloride peptide, is released from the pancreatic islets, intestine and stomach. Glucagon is released under hypoglycemic conditions and then elevates blood glucose levels, serving as a major counter hormone [1]. The regulation of

• The first report about the activity of ANAM

  2022-09-03

  

  The first report about the activity of ANAM in CACs it is due to Garcia et al. [19] which treated 16 cancer patients with oral ANAM 50mg once daily vs placebo for 3days followed by a washout Cathepsin Inhibitor 1 of 5–7days and then cross-over to the other group for 3 more days. It was described a w

• br Materials and methods br

  2022-09-03

  

  Materials and methods Results Discussion G-quadruplex structures are extensively studied for its role in central dogma of molecular biology viz. replication problems leading to chromosomal translocations [20], [21], transcriptional inhibition [32] and alternative splicing and translational

• br STAR Methods br Introduction Arsenite is

  2022-09-03

  

  STAR★Methods Introduction Arsenite is a well-recognized toxic metalloid that commonly presents in the natural environment. Chronic exposure to arsenite can lead to a wide range of adverse health effects to human, including cancers, cardiovascular diseases, diabetes, skin lesion and neurodegene

• Benzene metabolism occurs primarily in the liver

  2022-09-03

  

  Benzene metabolism occurs primarily in the liver where benzene is converted into phenol, catechol, hydroquinone (HQ). HQ is further converted to 1,4-benzoquinone (1,4-BQ) in the bone marrow which is the primary organ of benzene toxicity (Bolton et al., 2000). 1,4-BQ is an important benzene metabolit

• CGP 41251 receptor br Conclusion GST expression was detected

  2022-09-02

  

  Conclusion GST expression was detected in the Hemicornea construct and the commonly used animal cornea models at both the protein and functional levels. The results are summarized in Table 1. However, the construct exhibited lower levels of activity of GST, a marker of phase II enzymatic activity

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