• L1023 Anti-Cancer Compound Library: Precision Drug Discov...

  2025-09-30

  Explore how the L1023 Anti-Cancer Compound Library transforms cancer research with precision-targeted, cell-permeable compounds. Discover advanced strategies for biomarker-driven drug discovery and high-throughput screening of anti-cancer agents.

• Panobinostat (LBH589): Decoding HDAC Inhibition and Apopt...

  2025-09-29

  Explore the multifaceted action of Panobinostat, a potent hydroxamic acid-based histone deacetylase inhibitor, in cancer epigenetics. This article uniquely dissects how Panobinostat orchestrates apoptosis induction in cancer cells through advanced epigenetic and mitochondrial crosstalk, integrating new mechanistic insights beyond chromatin remodeling.

• L1023 Anti-Cancer Compound Library: Integrative Strategie...

  2025-09-28

  Discover how the L1023 Anti-Cancer Compound Library advances cancer research by enabling integrative, biomarker-driven discovery—specifically targeting novel molecules like PLAC1. Explore unique workflows that unite high-throughput screening and pathway analysis for next-generation oncology breakthroughs.

• Trichostatin A (TSA): HDAC Inhibition for Precision Epige...

  2025-09-27

  Explore how Trichostatin A, a potent HDAC inhibitor, drives precision epigenetic regulation in advanced cancer and organoid research. Uncover novel insights into TSA’s molecular action and its transformative role in bridging cell fate control with therapeutic innovation.

• Panobinostat (LBH589): Unraveling HDAC Inhibition and Mit...

  2025-09-26

  Discover how Panobinostat (LBH589), a broad-spectrum HDAC inhibitor, uniquely bridges histone acetylation and mitochondrial apoptosis pathways to overcome drug resistance in cancer cells. This article offers a novel analysis of LBH589’s mechanisms, integrating recent findings in epigenetic regulation research.

• Genotyping Kit for Insects, Tissues, Fishes & Cells: Next...

  2025-09-25

  Explore how the Genotyping Kit for target alleles of insects, tissues, fishes and cells transforms rapid genomic DNA preparation and single-tube extraction for advanced molecular biology genotyping research. This article reveals a deeper mechanistic understanding and novel applications beyond standard protocols.

• 3X (DYKDDDDK) Peptide: Unveiling Novel Mechanisms in Orga...

  2025-09-24

  Explore the unique features of the 3X (DYKDDDDK) Peptide in organelle lipidomics, recombinant protein purification, and metal-dependent antibody interactions. This in-depth analysis reveals new frontiers for the 3X FLAG peptide in mitochondrial biology and protein engineering.

• Cy3 TSA Fluorescence System Kit: Enhancing lncRNA Detecti...

  2025-09-23

  Explore how the Cy3 TSA Fluorescence System Kit advances detection of low-abundance biomolecules in cancer research, enabling precise analysis of lncRNA-mediated pathways. This article highlights technical strategies and scientific applications for next-generation signal amplification in immunohistochemistry.

• Aurora A overexpression is also related to the activation

  2025-04-22

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer InstaBlue Protein Stain Solution [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these g

• br ACL Regulation and Role in Lipid Metabolism ACL is

  2025-04-18

  

  ACL Regulation and Role in Lipid Metabolism ACL is a ubiquitous enzyme at the nexus of nutrient catabolism and synthesis of cholesterol and fatty acids. In mammals, it is highly expressed in lipogenic tissues including adipose, liver, and lactating mammary glands [9]. In the presence of ATP and C

• We also show that in both ATM proficient and deficient

  2025-04-17

  

  We also show that in both ATM proficient and deficient/mutant Nitrocefin the activation of ATR signaling is DSB complexity-dependent (Figs. 1, 4A, C and E, 6A and B). Wang et al. have also reported that the effects of ATR and CHK1 on radiosensitivity are independent of the NHEJ repair pathway [41],

• In vascular endothelial cells L

  2025-04-16

  

  In vascular endothelial cells, L-arginine produces nitric oxide (NO) under the action of nitric oxide synthase (NOS), and nitric oxide can activate guanylate cyclase to produce a large amount of cGMP, thereby relaxing vascular smooth muscle and expanding blood vessels. Numerous studies have confirme

• To clarify the molecular mechanism of maduramicin

  2025-04-12

  

  To clarify the molecular mechanism of maduramicin-induced apoptosis in chicken myocardial cells, the mRNA levels of bcl-2, bax, and cytochrome C, as well as the mRNA levels and activities of caspase-3/8/9 were determined. The mRNA expressions and activities of initiator casapase-9 and executioner ca

• br Materials and methods br

  2025-04-11

  

  Materials and methods Results Discussion In this study, we administrated BDE-153 to newborn rat pups at PND 10 and cultured primary neurons, measured neuronal apoptosis and LDH activity in vivo and in vitro, then explored the possible predominant pathway underlying the neuronal apoptosis by

• Prestained Protein Marker (Triple color, EDTA free, 10-250 k

  2025-04-11

  

  Apelin/APJ triggers a variety of cellular signaling pathways (Fig. 1). Recent studies from our laboratory showed that apelin-13 induces vascular smooth muscle cell (VSMC) proliferation by the upregulation of Cyclin D1 expression, which is involved in an ERK-dependent activation of Jagged-1/Notch3 si

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