• br Acknowledgements br Introduction Thus damage to

  2025-03-03

  

  Acknowledgements Introduction Thus, damage to the Benzoic acid metabolite may produce severe consequences (National Research Council, 1992). Indeed, though the nervous system has several compensatory and adaptive mechanisms, it is vulnerable to toxic insult, due to its inability to regenerate

• br Diabetes and obesity fit or fat sugar

  2025-03-03

  

  Diabetes and obesity: fit or fat; sugar or not: the autophagic verdict Type 2 diabetes and obesity are among the most emerging health problems worldwide. The factors that are responsible for the establishment of diabetes include decreased Deoxyadenosine production, rise in adiposity, and an incre

• Hepatoid adenocarcinoma closely resembles HCC and in some ca

  2025-03-01

  

  Hepatoid adenocarcinoma closely resembles HCC and in some cases can be indistinguishable morphologically. Hepatoid adenocarcinoma is an aggressive neoplasm, and metastasis to the liver is common [12]. Gastric metastasis from HCC has also been reported [27]. Distinguishing hepatoid adenocarcinoma fro

• Mitochondrial dysfunction resulting from mtDNA abnormalities

  2025-03-01

  

  Mitochondrial dysfunction resulting from mtDNA abnormalities may trigger retrograde signaling pathways from the mitochondrion to the nucleus, which regulate the expression of genes involved in diverse cellular processes, including metabolism, stress responses, tumor progression, nutrient sensing, li

• However one should keep in mind that these

  2025-03-01

  

  However, one should keep in mind that these results may not reflect exactly in vivo antioxidant activity. Many other issues such as absorption, metabolism and physicochemical properties of different antioxidants must also be considered (Prior et al., 2007, Wu et al., 2004). Some research groups are

• Long term blood pressure regulation is linked to renal

  2025-03-01

  

  Long term blood pressure regulation is linked to renal function through the mechanisms of pressure natriuresis (Evans et al., 2005), which has been shown to be modulated by the RAS (Hall et al., 1999). Key components of the RAS are expressed throughout the kidney, and are implicated in renal excreto

• In the current investigation we

  2025-03-01

  

  In the current investigation, we studied the effect of propofol on prostate cancer cells. Propofol is one of the most commonly used drugs in the critical care setting and for the induction of general anesthesia and moderate and deep sedation intraoperatively. Recent studies indicated that propofol e

• Hepatic inflammation and fibrosis are hallmarks

  2025-03-01

  

  Hepatic NMS-1286937 and fibrosis are hallmarks of the NASH phenotype and are thought to occur in a subset of patients with NAFLD. While it is hypothesized that therapeutic lowering of hepatic lipids will be sufficient to improve hepatic fibrosis and inflammation secondarily, this remains controvers

• Table reports the results for the categorical coding of

  2025-03-01

  

  Table 3 reports the results for the categorical coding of diagnosis. The categorical coding is less hypothesis driven than the continuous coding because it allows for nonlinear interactions that are driven by only two groups (CN → MCI stable, CN → MCI progressor, and CN → AD). That said, this analys

• Introduction Diabetic nephropathy is a rapidly growing cause

  2025-03-01

  

  Introduction Diabetic nephropathy is a rapidly growing cause of end-stage renal disease [1]. Glomerular, tubular and vascular toxicity resulting from hyperglycemia (glucotoxicity) have been evaluated extensively at the molecular level as contributing factors for diabetic nephropathy [[1], [2], [3]]

• In the past few years several experimental findings

  2025-03-01

  

  In the past few years, several experimental findings have demonstrated a pivotal involvement of adenosine also in driving the phenotypic switch of macrophages. In particular, the stimulation of A2A and A2B receptors seems to play a critical role in switching macrophages from M1 to M2 phenotype [37,6

• Moreover our results indicate that ADP is by far

  2025-03-01

  

  Moreover, our results indicate that ADP is by far a better phosphate donor than AMP (Table 2). Yet, the bindings of AMP and ATP are mutually exclusive, whereas the bindings of ADP and ATP are additive (Fig. 7). The multiplicity of the phosphate donors in the TgAK reaction (Tables 1 & 2), suggests th

• We aim to evaluate the AK in regulating adenosine signaling

  2025-03-01

  

  We aim to evaluate the AK in regulating adenosine signaling in the retina. It was reported that the degree of Sulindac injury directly depends on expression levels of AK and the resulting extracellular levels of adenosine (Boison, 2006). Indeed, transgenic mice overexpressing AK are highly suscepti

• br Methods br Transparency document br Introduction

  2025-03-01

  

  Methods Transparency document Introduction Epinephrine (EP) is a critical hormone and catecholamine neurotransmitter in nervous system of mammals.1, 2, 3 It has been known to accelerate and regulate heartbeat, blood pressure, bronchodilation, mydriasis, blood sugar and lipolysis, and can he

• Molecular docking simulations were carried out for ligands

  2025-03-01

  

  Molecular docking simulations were carried out for ligands – in the ACE crystal structure (1O86) and DPP4 crystal structure (2G5P). Comparison of the binding mode of – () with enalaprilat (a) in ACE shows that the phenethyl group (–, enalaprilat) occupies the S1 pocket and the adjacent carboxylic BH

16345 records 2/1090 page Previous Next 12345 下5页 Last page