• Since the first studies of betaine aldehyde oxidation in

  2024-04-25

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other PRIMA-1 as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of attention w

• Because activation of HT A receptor is

  2024-04-25

  

  Because activation of 5-HT2A receptor is capable of facilitating dopamine cell activity and dopamine release (Bortolozzi et al., 2003), and this action of dopamine is known to mediate rat maternal behavior, especially maternal motivation (Afonso et al., 2007, Febo et al., 2010, Li and Fleming, 2003,

• We investigated the role of ABT treatment in MAPKinase activ

  2024-04-25

  

  We investigated the role of ABT 702 treatment in MAPKinase activation in mouse microglia in vitro. In Fig. 7D immunocytochemistry results revealed that Iba1 and p-ERK1/2 co-localized in LPS induced mouse microglia. In our previous study we have reported that LPS activates ERK1/2 phosphorylation (Ahm

• Finally one can ask whether these results

  2024-04-25

  

  Finally, one can ask whether these results throw any light on the nature of the target in SNMG patients. Interestingly, the results of the in vitro incubations suggested that SNMG sera might increase AChR expression to a small extent, raising the possibility that SNMG patients, who have thymic chang

• Whereas more research is needed to identify the precise

  2024-04-25

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Cyclopamine that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the be

• The inhibition of the exacerbated inflammatory response that

  2024-04-25

  

  The inhibition of the exacerbated inflammatory response that follows injury may be an alternative approach to induce a more efficient repair [17,83]. In line with that, 5-LO is one of the most consolidated targets for dampening inflammation, mainly through the therapeutic effects of 5-LO inhibitors

• It was reported that overexpression

  2024-04-25

  

  It was reported that overexpression of the rat ACL gene in tobacco increased the total ACL activity by 4 fold, which increased the production of fatty acids by 16% [8]. Recently, a 1.7-fold increase of fatty acids and 1.9-fold increase of triacylglycerol (TAG) was observed in Aspergillus oryzae with

• A positive correlation between nasopharyngeal CCL and CCL

  2024-04-25

  

  A positive correlation between nasopharyngeal CCL3 and CCL5 [16] concentrations and illness severity was shown in evaluating patients with RSV bronchiolitis [17]. CCL5 and CCL3 are important for monocyte and lymphocyte recruitment to the lung during RSV infection [7], [16], [18]. Despite the signifi

• br Experimental br Results and discussion br Conclusion br A

  2024-04-25

  

  Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP

• Because ASK signaling in microglia and astrocytes is importa

  2024-04-25

  

  Because ASK1 signaling in microglia and astrocytes is important during EAE, we hypothesized that a combination therapy that targets T cells along with microglia and astrocytes would further ameliorate the severity of EAE. We tested this hypothesis by applying valproic pilocarpine hydrochloride (VPA

• THZ531 However one should keep in mind

  2024-04-24

  

  However, one should keep in mind that these results may not reflect exactly in vivo antioxidant activity. Many other issues such as absorption, metabolism and physicochemical properties of different antioxidants must also be considered (Prior et al., 2007, Wu et al., 2004). Some research groups are

• Although the interactions of PhLP

  2024-04-24

  

  Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls leuprolide acetate signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its interacting p

• br Declarations Funding None for the paper in question

  2024-04-24

  

  Declarations Funding: None for the paper in question. Competing interests: Florent Morio has received speaker's fees from Gilead, Basilea, and MSD and travel grants from Gilead, MSD, Pfizer, Basilea, and Astellas. Ethical approval: Not relevant for the paper in question. Introduction Lactic

• Although sex hormones activational effects are known to dire

  2024-04-24

  

  Although sex hormones (activational effects) are known to directly interact with RAS (Baiardi et al., 2005, Miller et al., 1999, Silbiger and Neugarten, 1995), the potential contribution of organizational hormonal and SCC effects on physiological sex-based difference in the regulation of the RAS rem

• Recently the FDA approved the first blood based test for

  2024-04-24

  

  Recently, the FDA approved the first blood-based test for the detection of EGFR mutations in non-small cell lung cancer patients (http://www.fda.gov) (Voelker, 2016). This allows detection of specific, recurrent mutations, which can help the selection of the patients that could benefit from Erlotini

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