• br Discussion A familial platelet

  2019-05-16

  

  Discussion A familial platelet disorder with a propensity to myeloid malignancy (FPD/MM) was first reported in 1978 and since then approximately 30 pedigrees with RUNX1 germline mutations have been reported in the literature [9,11]. The RUNX1 gene is composed of 10 exons (1–6, 7A, 7B, 7C and 8).

• br Disclosures and funding sources br Conflicts of interest

  2019-05-16

  

  Disclosures and funding sources Conflicts of interest Introduction In 1994, Leenhardt et al. first described electrocardiogram (ECG) findings of torsades de pointes and QT prolongation in patients without demonstrable structural TAE226 manufacturer disease, with the torsades de pointes ini

• In a recent study Nademanee et al

  2019-05-16

  

  In a recent study, Nademanee et al. [76]. reported additional evidence pointing to pathologic changes in the RVOT of patients with BrS that have proved undetectable by echocardiography or MRI. In contrast, imaging techniques in ARVC clearly display morphologic and functional changes (e.g., dilation

• ci-1033 At least genes are associated with familial

  2019-05-16

  

  At least 15 genes are associated with familial LQTS, with 3 of these genes accounting for 70–75% of cases [5]. Despite advances in the understanding of the molecular basis of LQTS, challenges remain in making the clinical diagnosis. Importantly, between 10–40% of gene carriers have normal QT interva

• This study provides an innovative model to harness

  2019-05-16

  

  This study provides an innovative model to harness national household survey data to quantify the effects of the various malaria control interventions. The model accounts for the spatial dependence in parasitaemia as a consequence of the heterogeneous distribution of malaria transmission and its dri

• br As the global burden of disease shifts

  2019-05-16

  

  As the global burden of disease shifts from infectious diseases to non-communicable diseases (NCDs), cancer has increasingly become a major contributor to morbidity and mortality in low-income and middle-income countries (LMICs). Major reasons for these nitric oxide synthase inhibitors shifts inc

• br Case report A year old man

  2019-05-16

  

  Case report A 63-year-old man with a history of longstanding atrial fibrillation (AF) was admitted to our hospital with anterior acute myocardial infarction (AMI). Emergency cardiac catheterization revealed chronic total occlusion of the distal right coronary artery, total occlusion of the proxim

• luteolin br Discussion Over the past two decades the

  2019-05-16

  

  Discussion Over the past two decades, the incidence of second primary malignancy has progressively risen among cancer survivors and is an issue of increasingly greater concern in oncology. The increasing incidence may be due to the elevated rate of early cancer detection, improved cancer treatmen

• br Case report At that time

  2019-05-16

  

  Case report At that time, her laboratory examinations showed hemoglobin (Hb) of 10.4 g/dl (normal: 11.3–15.3), and platelets of 36,000/mm3 (normal: 150,000–400,000), and WBC count of 3800/mm3 (normal: 4000–11,000). The liver function showed serum albumin was 3.2 g/dl, total bilirubin was 1.7 mg/d

• LQT can have numerous clinical manifestations ranging from

  2019-05-16

  

  LQT1 can have numerous clinical manifestations, ranging from no symptoms to sudden cardiac death, which reflects the heterogeneity in channel dysfunction. Mutation type, location, and even a patient׳s ethnic background, age, and gender are critical factors that affect the pathophysiology of the dise

• Human ether a go go related gene HERG encodes the

  2019-05-16

  

  Human-ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly-activating delayed-rectifier potassium BB-94 that generate IKr. This outward potassium current is elicited during the plateau phase of action potentials and is required for repolarization [4]. After being translated in the end

• isosafrole br Materials and methods br Results CRT devices w

  2019-05-15

  

  Materials and methods Results CRT devices were successfully implanted in 27 patients (70.7±10.1 years), and the LV leads were placed in the lateral branch or posterolateral branch. Baseline characteristics of all patients are listed in Table 1. Eighteen of 27 patients received a CRT defibrilla

• By GBD region in the past two decades the largest

  2019-05-15

  

  By GBD region, in the past two decades, the largest increases in incidence of ischaemic stroke were in eastern Europe, central and east Asia, north and sub-Saharan Africa, and the Middle East (figure 1), with the largest increase (22%) noted in the Democratic Republic of Congo. Notably, some of the

• hsp90 inhibitors En ese contexto Mart nez Estrada

  2019-05-15

  

  En ese contexto, Martínez Estrada, que se encontraba en México, fue encargado de recordar hsp90 inhibitors don Alfonso Reyes en representación de Argentina, y de pronunciar las palabras en reconocimiento a los 19 años de Cuadernos, junto con el poeta español Francisco Giner y el filósofo mexicano Lu

• The diagnosis of PTC based on

  2019-05-15

  

  The diagnosis of PTC, based on the Modified Dandy Criteria, is made when a patient exhibits an elevated LP opening pressure above 25cm H20 with normal CSF composition and radiologic findings, and no other explanation for the rise in intracranial pressure [6]. The most common presenting symptom occur

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